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Modulating a complex system carries the possibility of unintended effects that require careful study

The control group exhibits the highest neuron density, representing the baseline levels expected in healthy conditions

However, in juvenile but not adult human islets, exendin-4 stimulated calcineurin/NFAT signaling and enhanced expression of proliferation-promoting factors such as NFATC1, FOXM1, and CCNA1 [557]